We focus on refinement of human exposure
assessment for better risk characterization.
Human health is affected by several factors to which we are exposed on daily basis. One of the most important factors of concern are chemicals, pollutants and their mixtures which enter our body via oral, dermal or inhalation route and are subject to physiologicaly based pharmacokinetic processes that may affect their absorption, distribution, metabolism and excretion.
The fate of these substances in the human body, reactions at the site/mode of action, can cause risks to human health. Therefore, it is important to measure external exposure, but also to focus on internal exposure. Our group is dedicated to identify chemicals that can potentially enter the human body, modeling and predicting their pathways in the human body, subsequently assessing real health risks and also to analyze potential relationship between exposure and health outcomes in individual (cohort studies) and population levels. Our goal is to assess and refine human exposure in order to better characterize the risks.
Occupational exposure of Firefighters
Key words: cohort study, PFAS, other pollutants v.s. biomerkers of effect and biomarkers of exposure; Human DNA damage in vivo; DNA methylation as an epigenetic biomarker; suplementation, fitnes, other parameters
Pesticide mixtures
Key words: cohort study, suspect screening analysis, target analysis, urine samples (parent-child pairs), biomarkers of effect (oxidative stress, DNA damages, epigenetics), assessment of indoor DUST, GIS spatial analyzes of the possible impact of agriculture and pesticide applications
Genotoxicity
Key words: In vitro Genotoxicity potential assessment (human stem cells, procaryotic cell line, QIVIVE approach) – Benztriazoles and Probabilistic Human Health Risk Assessment
EXPOSOME
Key words: EXPOSOME approach in cohorts, Urban EXPOSOME, population data, external and internal exposure, blood, urine, mother milk samples, Air Quality, outdoor, indoor (PM, O3, NOx, POPs, EDC, PFAS, PBDE, Pest., NBFR, etc.), adverse health effects (population data and cohorts)
Retrospective exposure assessment – the use of biomonitoring studies for retrospective reconstruction of exposure by PBPK modeling (biomonitoring of breast milk in the human population in CR) and probabilistic human health risk assessment.
Indoor air sampling & inhalation risk assessment – exposure assessment of new POPs. Probabilistic risk assessment in human population (MonteCarlo simulation – Risk assessment)
The Experimental ex-vivo approach: on fully automated Franz cell system with human skin (Dermatotoxicokinetic parameters).
Targeted studies for refinement of exposure of selected chemical substances – SkinRISK project (Kinetics of the percutaneous penetration of optical isomers in sunscreens, brominated flame retardants and polar pesticides in dermal exposure) and use of these parameters for toxicokinetic (PBTK) models.
Toxicological characterization of UV filters – sunscreens – its fotodegradation products and optical izomers.
The development of new methods for external exposure assessment – ambient air – SENSORS – SMART CITIES.
