Dr. Martin Toul received the Rector's Prize for outstanding students of doctoral study programs.
In his Ph.D. thesis, Martin was involved in research in protein engineering and advanced enzyme kinetics. It is a field of research in which only a small number of research groups worldwide are involved. He aimed to unravel the molecular mechanisms of selected enzymes to optimize them for practical applications. The research focused on three groups of enzymes: luciferases, plasminogen activators, and haloalkane dehalogenases. Luciferases are enzymes that produce bioluminescent radiation. Plasminogen activators are thrombolytics, i.e., drugs that dissolve blood clots. Halogenases have applications in detecting and decontaminating toxic substances in the environment.
Martin identified limitations in the function of staphylokinases and showed that their removal could increase the efficiency of blood clot dissolution by up to ten thousand times.