Assoc. Prof. Klára Hilscherová
Head of "Bioanalytical toxicology" research group
Klára Hilscherová is an associate professor at the RECETOX research center at Masaryk University and the head of the Bioanalytical Toxicology research group. She received her Ph.D. in Environmental Chemistry and habilitated in Ecotoxicology at the RECETOX Centre of Masaryk University in 2016. During her Ph.D. studies, she studied for two years at the National Center for Food Safety and Toxicology at Michigan State University, USA. And she also worked as a postdoctoral researcher for two years after completing her Ph.D.
She has been involved in several international and national basis and applied research projects. And currently, Klára Hilscherová is the principal investigator for Masaryk University on the EU H2020 ERGO project and the EXPRO Basic Research Excellence Grant Project and co-investigator on other European projects. She is a member of the OECD International Expert Group on Methods for Detection of Thyroid Disruption, NORMAN Association (working groups Biotests and Biomarkers in Water Monitoring and Effect-Driven Analysis for Identification of Hazardous Substances), Society for Environmental Toxicology and Chemistry (SETAC) and Society of Toxicology (SOT).
Her research focuses primarily on the ability of substances to disrupt hormone regulation (endocrine disruption) and the associated risks to human health and the environment. She has broad experience in mechanistic and aquatic toxicology of pollutants and their mixtures, the development of biodetection tools, and in vitro systems for the characterization of toxic properties of substances or complex environmental samples, especially their ability to cause endocrine disruption. Her research group develops and optimizes innovative approaches for the study of toxic properties of substances, for risk assessment of chemical mixtures, and for identifying substances responsible for the detected effects. She is working on the characterization and potential use of harmful effect pathways and biomarkers mainly related to endocrine disruption and the effects of substances produced by aquatic cyanobacterial blooms.
Klára Hilscherová has published over 165 ISI WoS articles that have received over 6000 citations (h-index 45) and over 200 conference presentations, including 14 invited talks, 5 book chapters. As a supervisor, she regularly supervises undergraduate, MSc, and Ph.D. students and has supervised over 20 Ph.D. students.
Associate Professors
Scientific Researchers
Experts
Non-academic Staff
External People
Inactive employment status
Publications
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Adopting Mechanistic Molecular Biology Approaches in Exposome Research for Causal Understanding
ENVIRONMENTAL SCIENCE & TECHNOLOGY, year: 2024, volume: 58, edition: 17, DOI
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Cyanobacterial anatoxin-a does not induce in vitro developmental neurotoxicity, but changes gene expression patterns in co-exposure with all-trans retinoic acid
Toxicology Letters, year: 2024, volume: 391, edition: January 2024, DOI
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Cyanobacterial harmful bloom lipopolysaccharides: pro-inflammatory effects on epithelial and immune cells in vitro
Archives of Toxicology, year: 2024, volume: 98, edition: 2, DOI
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Endocrine disrupting potential of total and bioaccessible extracts of dust from seven different types of indoor environment
Journal of Hazardous Materials, year: 2024, volume: 469, edition: May 2024, DOI
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Identification of new endocrine disruptive transthyretin ligands in polluted waters using pull-down assay coupled to non-target mass spectrometry
Journal of Hazardous Materials, year: 2024, volume: 471, edition: June 2024, DOI
Projects
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Network for Cross-disciplinary assessment of Endocrine Disrupting compounds: training the next generation of toxicologists (101168892)
MU Researcher: doc. Mgr. Klára Hilscherová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2025 — 12/2028Investor: European Union / Horizon Europe -
Saving lives through research in early cancer detection and prevention: Molecular, genomic and societal factors (CZ.02.01.01/00/22_008/0004644)
MU Researcher: prof. RNDr. Jana Klánová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2024 — 6/2028Investor: Ministry of Education, Youth and Sports of the CR / OP JAK -
Identification of chemical and biological determinants, their sources, and strategies to promote healthier homes in Europe (101057499)
MU Researcher: Lisa Emily Melymuk, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 9/2022 — 8/2027Investor: European Union / Horizon Europe -
CETOCOEN Excellence (857560)
MU Researcher: prof. RNDr. Jana Klánová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2020 — 12/2026Investor: European Union / Horizon 2020 -
Studentský výzkum v oblastech environmentální toxikologie v roce 2025 (MUNI/A/1612/2024)
MU Researcher: prof. RNDr. Luděk Bláha, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2025 — 12/2025Investor: Masaryk University / Specific research - support for student projects
More information
Supervised theses
Field of study: Ecotoxicology
Topics of doctoral theses (supervisor)
- Biodetection systems in the assessment of endocrine disrupting potential of compounds in surface waters – graduate 2019
- Toxicological impacts of exposure to metal nanoparticles – graduate 2019
- Bioactive compounds in stagnant waters affected by water blooms – graduate 2018
- Endocrine-related toxicity of cyanobacteria and other agents in the aquatic environment – graduate 2017
- Advanced in vivo biotests in ecotoxicology of contaminated waters and waste waters – graduate 2016
- Biotests for assessment of presence of endocrine active compounds in surface and waste waters – graduate 2013
Topics of doctoral theses (consultant)
- Bioassays for studies of specific toxicity in mixtures of environmental contaminants – graduate 2014
Field of study: Environmental Chemistry
Topics of doctoral theses (supervisor)
- Specific mechanisms of action of pollutant mixtures in the environment – graduate 2014
- New toxicity mechanisms of important organic contaminants – graduate 2012
- Biomarkers in experimental ecotoxicology – graduate 2012
- In vitro cell bioassays for ecotoxicological assessment of environmental mixtures – graduate 2012
Field of study: Environmental chemistry and toxicology
Topics of doctoral theses (supervisor)
- Linking retinoid and thyroid hormone signaling disruption with adverse effects on early development – ongoing study
- Health risks of natural toxins in surface waters – graduate 2022
Field of study: Environmental chemistry and toxicology
Topics of doctoral theses (supervisor)
- Toxicological Characterization of Environmental Exposure Mixtures – ongoing study
- Disruption of thyroid regulation associated with adverse effects of environmental pollutants – ongoing study
- Schopnost relevantních expozičních směsí a prioritních polutantů narušovat hormonální regulaci – ongoing study
- Endocrine disrupting potential of compounds from indoor environment – ongoing study
- Effects of compounds and their mixtures in aquatic environment on early development of fish – graduate 2021
- Evaluation of the toxic potential of compounds from atmospheric matrices – graduate 2020
- Characterization of specific effects of metabolites of cyanobacteria and algae – graduate 2020
- Chemical diversity of cyanobacterial metabolites in the environment – graduate 2020
Field of study: Environmental chemistry and toxicology
Topics of doctoral theses (supervisor)
- Nuclear receptors role in effects of algal and cyanobacterial metabolites – ongoing study