Dr. Zdeněk Spáčil
PI of "Biomarkers of health and disease" research group
Dr. Zdeněk Spáčil holds a dual doctoral degree in analytical chemistry (2010) awarded from both Stockholm University, Faculty of Science (Sweden) and Charles University in Prague, Faculty of Pharmacy (Czech Republic). As a postdoctoral fellow (2010-2012) and later a research scientist (2014-2015) at the University of Washington, he worked under the tutelage of professors Tureček and Gelb. Currently, he is an assistant professor at Masaryk University, leading a newly established research group at the RECETOX Centre. He researches in the development of advanced analytics for metabolomics and targeted proteomics applied to functional characterization of microbiota, aging-induced metabolic and immunomodulatory modulations relevant to Alzheimer’s disease and pioneering the Exposome (i.e., non-genetic factors affecting human health).
He has expertise in instrumental analytical chemistry (i.e., mass spectrometry, separation science) and clinical chemistry. He substantially contributed to the National Institutes of Health NIH/NIDDK funded projects (Univ. of Washington, Seattle) and the Bill and Melinda Gates Foundation Grants (Institute for Systems Biology, Seattle). Currently, he is a principal investigator on several projects funded by the Czech Science Foundation (GACR project No. 17-24592Y), the Grant Agency of the Masaryk University (GAMU project No. MUNI/G/1131/2017) and the Czech Health Research Council (AZV project No. NV19-08-00472).
He published 29 research items in JCR-SCI journals with over 700 citations (excluding self-citations, h-index=15). He was leading author on 13 publications (9 first authorship; 6 corresponding authorship; 4 last authorship), and he also authored four patent applications.
He has extensive experience supervising Ph.D. students and postdoctoral fellows at the international level. He is currently a supervisor of five graduate students and a number of undergaduates.
Assistant Professors
Non-academic Staff
Publications
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Cyanotoxin cylindrospermopsin disrupts lipid homeostasis and metabolism in a 3D in vitro model of the human liver
Chemico-Biological Interactions, year: 2024, volume: 397, edition: July 2024, DOI
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High-Throughput Microbore LC-MS Lipidomics to Investigate APOE Phenotypes
Analytical chemistry, year: 2024, volume: 96, edition: 1, DOI
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Application of the mass spectrometry to identify protein markers of Alzheimer's disease
Year: 2023, type: Conference abstract
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Cerebral organoids derived from patients with Alzheimer´s disease with PSEN1/2 mutations have defective tissue patterning and altered development
CELL REPORTS, year: 2023, volume: 42, edition: 11, DOI
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Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate
Molecular Neurodegeneration, year: 2023, volume: 18, edition: 1, DOI
Projects
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Výzkum studentů v oblastech chemie životního prostředí, hodnocení rizik a vztahů ke zdraví, v roce 2024 (MUNI/A/1515/2023)
MU Researcher: prof. RNDr. Jana Klánová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2024 — 12/2024Investor: Masaryk University / Specific research - support for student projects -
Alternativní přístupy v hodnocení mužské reprodukční toxicity chemických směsí bez využití zvířat (GA22-30004S)
MU Researcher: RNDr. Iva Sovadinová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2022 — 12/2024Investor: Czech Science Foundation / Standard Projects -
Výzkum studentů v oblastech chemie životního prostředí, hodnocení rizik a vztahů ke zdraví, v roce 2023 (MUNI/A/1117/2022)
MU Researcher: prof. RNDr. Jana Klánová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2023 — 12/2023Investor: Masaryk University / Specific research - support for student projects -
Klinicky relevantní biochemické, imunologické a buněčné biomarkery Alzheimerovy nemoci a stárnutí (NV19-08-00472)
MU Researcher: PharmDr. Zdeněk Spáčil, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 5/2019 — 12/2023Investor: Ministry of Health of the CR / Ministry of Health Research Programme 2015 - 2022 -
CETOCOEN Plus (CZ.02.1.01/0.0/0.0/15_003/0000469)
MU Researcher: prof. RNDr. Jana Klánová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 11/2015 — 6/2023Investor: Ministry of Education, Youth and Sports of the CR / Operational Programme Research, Development and Education
More information
Supervised theses
Field of study: Computational biology, bioinformatics and modelling
Topics of doctoral theses (supervisor)
- Mass Spectrometry Based Metabolomics and Lipidomics – graduate 2022
Field of study: Environmental chemistry and toxicology
Topics of doctoral theses (supervisor)
- Metabolic and protein biomarkers associated with gut microbiota – graduate 2023
Field of study: Environmental chemistry and toxicology
Topics of doctoral theses (supervisor)
- Methods for quantification of immunological markers by mass spectrometry technique – graduate 2023
- Characterization of lipid biomarkers of Alzheimer's disease – graduate 2023
- Development of Mass Spectrometry Methods for the Quantification of Protein Markers Relevant to Alzheimer's Disease – graduate 2023