Prof. Julie Dobrovolná
(previously Julie Bienertová-Vašků)
PI of "Environmental physiology" research programme
Julie Dobrovolná (previously Bienertová-Vašků) completed her Ph.D. in Pathophysiology in 2009 at Masaryk university and has been Associate Professor of Physiology and Pathophysiology at the Masaryk university since 2013. In 2003 and 2008, she took the visiting researcher position in INSERM Unit U781, Necker Hospital, Paris and where she collaborated on the project supervised by Dr. Agnes Rötig and Prof. A. Munnich. Since then, she has developed multiple international collaborations with excellent institutions (Dr. D. Fairweather at Mayo Clinic, US; prof. T. Lotti at University of Studies Guglielmo Marconi, IT, dr. P. Joshi at University Edinburgh, UK, the team of prof. Vandesompele at Center of Medical Genetics at Ghent University, Belgium and others).
Her expertise lies mainly in the assessment of environmental influences on human health outcomes, with special emphasis on changes in adipokine expression under different environmental conditions and on their involvement in molecular pathophysiology of obesity. Her current programme is mainly focused on identification of associations between environmental exposure and alterations in adipose tissue in humans. She has additional interest in development of novel methodology for measurement of stress and in re-definition of general concepts of stress.
She has published more 74 WOS articles, has >780 citations in WOS, h-index 15. Prof. Dobrovolná served as editor to and co-authored several monographies and monography chapters focused mainly on body fat and its role in pathophysiology of complex diseases. Prof. Dobrovolná has also a EPO/Japanese patent: EP2888275 A1- B-cell activating factor for increasing mucosal immunity of infants as well as sucklings and a preparation containing this factor that is based solely on the findings of her team.
Prof. Dobrovolná received numerous prizes: 2014 - Masaryk University Rector’s Award for the Young Scientist; 2009 – 2nd place in the Prix de Pharmacie national competition held under the auspices of the French Embassy of the Czech Republic and Sanofi-Aventis company; 2003 – 1st place in the Prix de Medecine national competition held under the auspices of the French Embassy of the Czech Republic; 2003 – Masaryk University Rector’s Award. Also, she mentored and supervised multiple future awardees of these awards (Martin Horak, Ivo Necesanek, Jan Novak) and for years has been participating within the jury of these awards.
She teaches numerous courses both at the Faculty of Medicine and Faculty of Sciences MU, including Pathological Physiology, Genetics, Human Molecular Biology, and Obesitology. She is also a member of the doctoral board in the field of Pathological Physiology. She has successfully supervised the total of 14 MSc/BSc students who successfully defended their theses in Biochemistry, Nutritional Therapy and Molecular Biology and currently supervises the total of 8 Ph.D. students with one successfully having graduated already.
Prof. Dobrovolná is also participating in numerous PR activities of the Masaryk University and organization thereof: annual organization of the Scientists’ Night and annual round of Children’s University (MjUNI) and is a recognized speaker (TEDx talk, ScienceCafé, ScienceSlam activities, promotion of autism awareness). She is also a guarantor of the “Healthy people” part of the strategy Brno2050 in the framework of smart-cities project in her residental city of Brno.
Publications
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Correlating plasma protein profiles with symptomatology and treatment response in acute phase and early remission of major depressive disorder
Frontiers in Psychiatry, year: 2024, volume: 15, edition: September 2024, DOI
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Endocrine disruption of adipose physiology: Screening in SGBS cells
Journal of Applied Toxicology, year: 2024, volume: 44, edition: 11, DOI
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How We Perceive Places: Measuring Biomarkers of Stress in Urban Environments Using Personal Exposure Sensors, Deep Learning and Functional Data Analysis
Year: 2024, type: Conference abstract
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Physiological evidence of stress reduction during a summer Antarctic expedition with a significant influence of previous experience and vigor
Nature Scientific Reports, year: 2024, volume: 14, edition: 1, DOI
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Socioeconomic status and adiposity in childhood cancer survivors: A cross-sectional retrospective study
Plos One, year: 2024, volume: 19, edition: 2, DOI
Projects
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Výzkum studentů v oblastech chemie životního prostředí, hodnocení rizik a vztahů ke zdraví, v roce 2025 (MUNI/A/1617/2024)
MU Researcher: prof. RNDr. Jana Klánová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2025 — 12/2025Investor: Masaryk University / Specific research - support for student projects -
Vylepšení stavu doprovodné cyklistické infrastruktury na Univerzitním kampusu Bohunice (MUNI/CF/1736/2022)
MU Researcher: Tadeáš Dvořák, MSc MU Faculty or unit: Faculty of Science Project Period: 3/2023 — 6/2025Investor: Masaryk University / ComMUNIty Fund -
Klinické a proteomické biomarkery predikujcí reverzní remodelování levé komory u pacientů s nově zjištěnou dilatační kardiomyopatií (NU22-02-00418)
MU Researcher: MUDr. Jan Novák, Ph.D. MU Faculty or unit: Faculty of Medicine Project Period: 5/2022 — 12/2025Investor: Ministry of Health of the CR / Ministry of Health Research Programme 2020 - 2026 -
Neurobiological and psychological markers of war-related stress in civilian population: a two-generation study of Balkan war survivors (NU22-04-00661)
MU Researcher: prof. MUDr. Ivan Rektor, CSc. MU Faculty or unit: Central European Institute of Technology Project Period: 5/2022 — 12/2025Investor: Ministry of Health of the CR / Ministry of Health Research Programme 2020 - 2026 -
Výzkum studentů v oblastech chemie životního prostředí, hodnocení rizik a vztahů ke zdraví, v roce 2024 (MUNI/A/1515/2023)
MU Researcher: prof. RNDr. Jana Klánová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2024 — 12/2024Investor: Masaryk University / Specific research - support for student projects
More information
Supervised theses
Field of study: Computational biology, bioinformatics and modelling
Topics of doctoral theses (supervisor)
- Urban Stress and Its Biomarkers: Investigating the Effects of Exposure to Built and Natural Environments – ongoing study
- Trajectory of Acute and Chronic Stress in Humans Subjected to Isolation Experiments (Space Research and Isolated Geographical Locations) – graduate 2024
Field of study: Environmental chemistry and toxicology
Topics of doctoral theses (supervisor)
- Biomarkers of intertissue dialogue between muscle, adipose and bone tissue – ongoing study
Field of study: Kinanthropology
Topics of doctoral theses (supervisor)
- The effect of resistance training and yoga on quality of life and muscle strength in adolescents and young adults after cancer treatment – ongoing study
- Psychological and physiological aspects of managing acute stress and selfdefence performance in model conflict scenarios. – ongoing study
Field of study: Molecular and Cell Biology and Genetics
Topics of doctoral theses (supervisor)
- Evolutionary mechanisms affecting the fixation of specific rates of aging in sexually reproducing organisms – graduate 2021
- Clarification of FSTL1 protein function in mitochondrial energy metabolism in vitro and in heart failure – graduate 2019
Field of study: Pathological Physiology
Topics of doctoral theses (supervisor)
- Association of proteomic markers with body composition – graduate 2024
- Analysis of objects in the cardiovascular ultrasound sequences and their implementation in the new diagnostic procedures – graduate 2022
- The pathophysiological role of nutritional determinants of growth in Central European children and adolescents – graduate 2021
- Entropy in relation to the initiation/course of a stress response and its connection with the transgenerational transmission of information – graduate 2021
Field of study: Physiology and Pathological Physiology
Topics of doctoral theses (supervisor)
- The role of omentin-1 in pathophysiology of complex diseases – graduate 2017
- Molecular biological methods for studying cells redox state in prostate carcinoma – graduate 2014
Teaching
Courses taught
Spring 2025 at Faculty of Medicine
- Doctoral thesis preparation
- Genetics
- Obesitology II - lecture
- Obesitology II - practice
- Pathological Physiology II - lecture (aZLPF0622p, EMPF0622p, ZLPF0622p)
- Pathological Physiology II - practice
- Pathophysiology II - lecture (aVLPF0622p, VLPF0622p)
- Research training IV