prof. RNDr. Jana Klánová, Ph.D.
Research programme coordinator, RECETOX director
| phone: | +420 549 49 5149 |
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Environmental chemistry and modeling
The research program has long been focused on obtaining experimental data on the state and contamination of the environment, including its impact on humans, modeling the transport and distribution of environmental pollutants and their accumulation in living organisms, and predicting related risks. In line with the RECETOX research strategy, new approaches to the assessment of complex environmental exposures, including the study of human exposure (ie a set of factors that may negatively affect population health), are being developed in this program.
The main objectives of the research are:
- developing innovative sampling and analytical techniques for multidisciplinary evaluation of complex mixtures of chemicals present in environmental and human tissue samples, including monitoring of their metabolites and biomarkers for their action in the body
- obtaining new data on exposure to environmental and biological organisms and levels of selected biomarkers
- studying sources and emissions, modeling of distribution and behavior of toxic substances in the environment and organisms and related health risks
- providing comprehensive data for new legislation, responsible management of chemicals and reducing health risks.
The aim of the research is not only to identify the substances and chemical mixtures to which the population is exposed, but also to identify their sources and exposure routes, as well as the most vulnerable population groups to be protected when developing new chemical management measures. Innovative sampling and analytical methods are used to measure contamination of environmental samples, biological samples and human tissues to identify actual exposure patterns.
Data on the presence of specific chemicals mixtures indoor and outdoor air, dust, water, food and products are combined with data on contamination of bodily fluids and tissues of selected population groups and information on their lifestyle and health. Particular emphasis is placed on examining differences in exposure patterns in relation to socio-demographic, behavioral and health characteristics. The use of state-of-the-art models makes it possible to estimate the actual exposure of different population groups and the chemical risks, thus encouraging the adoption of new measures for the safe management and protection of human health from their effects.
Heads of Research Groups
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prof. RNDr. Jana Klánová, Ph.D.
Human exposome
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prof. Gerhard Lammel, PhD.
Chemodynamics of environmental pollution
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doc. Ing. Branislav Vrana, PhD.
Chemodynamics of environmental pollution
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Lisa Emily Melymuk, Ph.D.
Chemical pollutants and human exposure routes
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prof. Martin Scheringer, Dr. sc. nat.
Pharmacokinetic modeling
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Mgr. Klára Komprdová, Ph.D.
Pharmacokinetic modeling
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PharmDr. Zdeněk Spáčil, Ph.D.
Biomarkers of health and disease
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Elliott James Price, PhD
Junior PI - Human exposome
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Mgr. et Mgr. Jiří Kalina, Ph.D.
Junior PI - Human exposome
Junior PIs
Research programs
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Environmental chemistry and modelling
The research programme focuses on understanding the mechanisms and processes affecting the emissions and fate of chemicals in the environment and further expands its interest in study of the exposure of individuals and populations to the environment in order to provide tools for common interpretation of data from environmental monitoring and human biomonitoring networks.
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Environmental health
The new research program deals with biomarkers of exposure, effect and sensitivity of individual organisms, and other factors such as socio-economic determinants of health, nutrition or physical activity. In this context, we are strengthening technology capabilities for omics analyses, biobanking capacities and developing a bioinformatics platform to support the interpretation of multi-omics and epidemiological data.
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Environmental Toxicology
Programme focuses on the environmental impacts of both acute and chronic chemical exposures. We use the Adverse Outcome Pathway (AOP) combining modeling and testing strategies to predict the environmental impacts of complex chemical mixtures. We investigate combined exposures to various factors that, based on individual susceptibility, can significantly contribute to an individual's excessive burden and lead to the development of pathologies.
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Chemical Tools for Diagnostics and Therapy
The programme focuses on the development of new photoactivatable systems and supramolecular carriers as specific systems that exhibit specific biological activities or serve as auxiliary systems for biological or medical applications.
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Loschmidt laboratories of Protein Engineering
The research programme has been dealing with the basic principles of enzymatic catalysis and development of protein and cellular biocatalysts for environmental, chemical and biomedical applications. The program uses protein engineering, synthetic biology and analysis of large data stored in genomic databases to develop and prepare useful catalysts.